Anti-HIV cytotoxicity enzyme inhibition and molecular docking studies of quinoline based chalcones as potential non-nucleoside reverse transcriptase inhibitors (NNRT)
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- 作者：Asima Hameeda ; Muhammad Imran Abdullaha ; imranchemist.ali@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ejaz Ahmeda ; dr.ejaz.ahmed@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ahsan Sharifa ; Ahmad Irfanb ; c ; Sara Masoodd
- 关键词：VGIADQMPNCXBHL-VQHVLOKHSA-N ; KCIUTVFYGJMWTC-SOFGYWHQSA-N ; ZPLWBJGDXRDLNB-WEVVVXLNSA-N ; CBWJFBGDNVYLJE-XBXARRHUSA-N ; GBVFUHANOGHFBF-WEVVVXLNSA-N ; YGFONNIITAZYLE-UXBLZVDNSA-N ; ZGGWEUHTNVNGOL-HWKANZROSA-N ; PPAKHLQEOXETKT-HWKANZROSA-N ; WODVNQKBWBZTIJ-HWKANZROSA-N ; ZJFDWXBUYWWPPT-FNORWQNLSA-N ; XTWBDIMTWLWPKM-GQCTYLIASA-N ; RFBVFEIQNRHFAR-FNORWQNLSA-N ; JZTJMCRSYPGCOI-ZZXKWVIFSA-N ; DSAWMPZECFYFHV-VMPITWQZSA-N
- 刊名：Bioorganic Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：65
- 期：Complete
- 页码：175-182
- 全文大小：1270 K
文摘
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Their reverse transcriptase RT inhibition activity was evaluated by using method of Minimum Inhibitory Concentration (MIC).
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Tested compounds displayed potential inhibition activity against reverse transcriptase RT.
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Docking studies of chalcones A1-A14 with non-nucleoside binding pocket of reverse transcriptase RT were performed.
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Better binding affinities were achieved with novel inhibitors than commercial ones.
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