Determination of American ginseng saponins and their metabolites in human plasma, urine and feces samples by liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
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- 作者：Jin-Yi Wana ; b ; c ; Chong-Zhi Wangc ; Zhi Liuc ; Qi-Hui Zhangc ; Mark W. Muschd ; Marc Bissonnetted ; Eugene B. Changd ; Ping Lib ; Lian-Wen Qib ; c ; fleude@126.com" class="auth_mail" title="E-mail the corresponding author ; Chun-Su Yuanc ; CYuan@dacc.uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：American ginseng ; Ginsenosides ; Enteric ; Microbiota ; Ginsenoside Rb1 ; Compound K ; LC-Q-TOF-MS
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：1015-1016
- 期：Complete
- 页码：62-73
- 全文大小：2817 K
文摘
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American ginseng saponins and their metabolites in human plasma, urine and feces after oral administration by LC-Q-TOF-MS.
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The ginseng constituents and metabolites were characterized, including 5 metabolites in plasma, 10 in urine, and 26 in feces.
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The levels of Rb1 and compound K were determined, and compound K had remarkably high level in all three kinds of biosamples.
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Ginsenoside Rk1 and Rg5, Rk3 and Rh4, Rg6 and F4 were detected as the products of dehydration in human feces.
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