Injection of human herpesvirus-8 in human skin engrafted on SCID mice induces Kaposi's sarcoma-like lesions

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• 作者：Foreman ; Kimberly E. ; Friborg ; Jacques ; Chandran ; Bala ; Katano ; Harutaka ; Sata ; Tetsutaro ; et. al.
• 关键词：AIDS ; Angiogenesis ; Animal model ; Kaposi's sarcoma-associated herpesvirus ; Viral pathogenesis
• 刊名：Journal of Dermatological Science
• 出版年：2001
• 出版时间：July, 2001
• 年：2001
• 卷：26
• 期：3
• 页码：182-193
• 全文大小：727 K

文摘

Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) has been implicated in the development of Kaposi's sarcoma (KS) and several B-cell lymphoproliferative diseases. Serologic and molecular genetic association data has implicated HHV-8 as the causal agent of KS, but its role in the development of KS lesions is not understood. To examine the etiology of KS, HHV-8 was injected into normal human skin transplanted onto SCID mice. Injection of HHV-8 induced lesion formation that is morphologically and phenotypically consistent with KS, including the presence of angiogenesis and spindle-shaped cells latently infected with HHV-8. These findings suggest that HHV-8 is indeed the etiologic agent of KS, and that the virus plays an important role in initiation of this disease.