Mechanisms, organisms and markers of infection in pregnancy

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• 作者：Garland ; Suzanne M. ; Ní ; Chuileanná ; in ; Fiona ; Satzke ; Catherine ; Robins-Browne ; Roy
• 关键词：Pre-term birth ; Pathogenesis ; Cytokines ; Infections
• 刊名：Journal of Reproductive Immunology
• 出版年：2002
• 出版时间：October - November, 2002
• 年：2002
• 卷：57
• 期：1-2
• 页码：169-183
• 全文大小：191 K

文摘

Premature delivery is still a significant problem in Obstetrics. It has multiple causes, with around 50 % thought due to infection. Of note infection as a pathogenesis is more likely in those pre-term births occurring <30 weeks gestation and is largely sub-clinical. Potential pathogens largely arise from the ascending route and from the endogenous vaginal flora, causing chorioamnionitis. Resultant morbidity from the release of endo+/exotoxins from such pathogens, the stimulation and production of inflammatory cytokine pathways, prostaglandins, metalloproteinases includes maternal sepsis (chorioamnionitis, septicaemia, post-partum endometritis), pre-term delivery (infant pre-maturity and its consequences, increased susceptibility to cerebral palsy and neonatal sepsis). As well, infection increases mortality due to fetal loss (extreme pre-maturity) as well as severe neonatal sepsis.