Traditional Chinese medicine therapy improves the survival of systemic lupus erythematosus patients

详细信息    查看全文

• 作者：Yi-Chun Ma ; MD ; MMS^a ; ^b ; Cheng-Chieh Lin ; MD ; PhD^c ; ^d ; ^e ; Chia-Ing Li ; PhD^d ; ^e ; Jen-Huai Chiang ; MPh^f ; ^g ; Tsai-Chung Li ; PhD^g ; ^h ; ⁱ ; ^{tcli@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author} ; Jaung-Geng Lin ; CMD ; MD ; PhD^a ; ^{jglin@mail.cmu.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Traditional Chinese medicine (TCM) ; Systemic lupus erythematosus (SLE) ; Survival
• 刊名：Seminars in Arthritis and Rheumatism
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：45
• 期：5
• 页码：596-603
• 全文大小：365 K

文摘

No previous studies have evaluated the effect of traditional Chinese medicine (TCM) treatment on the survival of patients with systemic lupus erythematosus (SLE). Hence, in this study, we determined whether TCM treatment affects the survival of SLE patients.

Methods

This nationwide population-based retrospective cohort study assessed 23,084 patients newly diagnosed with SLE between 1999 and 2009, using the database of the Taiwan National Health Insurance program.

Results

Among these patients, 9267 (40.15%) used TCM for SLE treatment and exhibited a significantly decreased risk of death [hazard ratio (HR) = 0.73; 95% confidence interval (CI): 0.68–0.78], with multivariate adjustment, compared with those without TCM use. A similar significant protective effect of TCM use was found across various subgroups of comorbidities. TCM use 1 year before diagnosis also reduced the risk of death. Our study findings indicated that Zhi Bo Di Huang Wan (HR = 0.54; 95% CI: 0.32–0.91), Jia Wei Xiao Yao San (HR = 0.35; 95% CI: 0.16–0.73), Liu Wei Di Huang Wan (HR = 0.51; 95% CI: 0.28–0.93), Gan Lu Yin (HR = 0.40; 95% CI: 0.17–0.96), and Yin Qiao San (HR = 0.22; 95% CI: 0.05–0.86) were the most effective TCM agents that improved survival.

Conclusions

This nationwide retrospective cohort study provided information that combined therapy with TCM may improve the survival in SLE patients. This study also suggests that TCM may be used as an integral element of effective therapy for SLE.