The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals
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- 作者：A. Alicia Koblansky1 ; 7 ; 8 ; Agnieszka D. Truax1 ; 7 ; 8 ; Rongrong Liu1 ; 2 ; 8 ; Stephanie A. Montgomery1 ; 3 ; Shengli Ding4 ; Justin E. Wilson1 ; 7 ; W. June Brickey1 ; 7 ; Marcus Mü ; hlbauer5 ; Rita-Marie T. McFadden1 ; Peizhen Hu6 ; Zengshan Li6 ; Christian Jobin5 ; Pauline Kay Lund4 ; Jenny P.-Y. Ting1 ; 7 ; jenny_ting@med.unc.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：22 March 2016
- 年：2016
- 卷：14
- 期：11
- 页码：2562-2575
- 全文大小：5704 K
文摘
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NLRX1 mitigates tumorigenesis in a genetic model of sporadic colon cancer, APCmin/+
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Nlrx1−/− colons have increased activation of tumor inducing STAT3, NFκB, MAPK, and IL6
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Anti-IL6R therapy reduces mortality and tumor development in Nlrx1−/−APCmin/+ mice
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Human colon tumors exhibit significantly lower levels of NLRX1 in multiple datasets
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