Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease

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• 作者：Sahar Kohanim ; MD¹ ; ^&lowast ; ; Sotiria Palioura ; MD ; PhD² ; ^&lowast ; ; Hajirah N. Saeed ; MD³ ; ^&lowast ; ; Esen K. Akpek ; MD⁴ ; Guillermo Amescua ; MD² ; Sayan Basu ; MBBS ; MS⁵ ; Preston H. Blomquist ; MD⁶ ; Charles S. Bouchard ; MD⁷ ; John K. Dart ; DM ; FRCOphth⁸ ; Xiaowu Gai ; PhD³ ; José ; A.P. Gomes ; MD⁹ ; Darren G. Gregory ; MD¹⁰ ; Geetha Iyer ; MD ; FRCS Glasgow¹¹ ; Deborah S. Jacobs ; MD³ ; ¹² ; Anthony J. Johnson ; MD¹³ ; Shigeru Kinoshita ; MD ; PhD¹⁴ ; Iason S. Mantagos ; MD¹⁵ ; Jodhbir S. Mehta ; MBBS¹⁶ ; Victor L. Perez ; MD² ; Stephen C. Pflugfelder ; MD¹⁷ ; Virender S. Sangwan ; MBBS ; MS⁵ ; Kimberly C. Sippel ; MD¹⁸ ; Chie Sotozono ; MD ; PhD¹⁴ ; Bhaskar Srinivasan ; MD ; MS¹¹ ; Donald T.H. Tan ; FRCS ; FRCOphth ; FAMS¹⁶ ; Radhika Tandon ; MD ; FRCOphth ; FRCSEd¹⁹ ; Scheffer C.G. Tseng ; MD ; PhD²⁰ ; Mayumi Ueta ; MD ; PhD¹⁴ ; James Chodosh ; MD ; MPH³ ; ^{James_Chodosh@meei.harvard.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：amniotic membrane transplantation ; apoptosis ; drug-induced disease ; immune-mediated disease ; keratinocyte death ; keratoprosthesis ; ocular surface reconstruction ; Stevens-Johnson Syndrome ; toxic epidermal necrolysis
• 刊名：The Ocular Surface
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：14
• 期：2
• 页码：168-188
• 全文大小：4220 K

文摘

Our purpose is to comprehensively review the state of the art with regard to Stevens- Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with particular attention to improving the management of associated ocular surface complications. SJS and TEN are two ends of a spectrum of immune-mediated disease, characterized in the acute phase by a febrile illness followed by skin and mucous membrane necrosis and detachment. Part I of this review focused on the systemic aspects of SJS/TEN and was published in the January 2016 issue of this journal. The purpose of Part II is to summarize the ocular manifestations and their management through all phases of SJS/TEN, from acute to chronic. We hope this effort will assist ophthalmologists in their management of SJS/TEN, so that patients with this complex and debilitating disease receive the best possible care and experience the most optimal outcomes in their vision and quality of life.