A soluble form of human nectin-2 impairs exocrine secretion of pancreas and formation of zymogen granules in transgenic mice
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- 作者：Yukiko Tomiokaa ; b ; ytomi@muses.tottori-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshikazu Fujimotoc ; d ; yosikazu@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kanji Nakaid ; nakai@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Kinuyo Ozakid ; k-ozaki@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Sayo Yamamotod ; ysayo@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Haruka Suyamad ; sharuka@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masami Morimatsub ; e ; mmorimat@vetmed.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Toshihiro Itoa ; toshiito@muses.tottori-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Etsuro Onoa ; c ; d ; etsuro@anim.med.kyushu-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：Soluble nectin-2 ; Pancreas ; Exocrine abnormality ; Endoplasmic reticulum ; Transgenic mice
- 刊名：Biochemistry and Biophysics Reports
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：5
- 期：Complete
- 页码：196-202
- 全文大小：2990 K
文摘
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We generated transgenic mice expressing a soluble nectin-2 (hNectin-2Ig Tg).
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hNectin-2Ig Tg exhibited abnormal formation of zymogen granules.
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Abnormal proteins were accumulated in dilated ER of acinar cells of hNectin-2Ig Tg.
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hNectin-2Ig Tg is new animal model for exocrine defects associated with ER stress.
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