Dusquetide: A novel innate defense regulator demonstrating a significant and consistent reduction in the duration of oral mucositis in preclinical data and a randomized, placebo-controlled phase 2a clinical study
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- 作者：Mahesh Kudrimotia ; Amarintha Curtisb ; Samar Azawic ; Francis Wordend ; Sanford Katze ; Douglas Adkinsf ; Marcelo Bonomig ; Jenna Elderh ; Stephen T. Sonisi ; j ; Richard Straubek ; Oreola Doninik ; odonini@shaw.ca" class="auth_mail" title="E-mail the corresponding author ; ODonini@Soligenix.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dusquetide (PubChem CID ; 71722017) ; Dextran sulfate sodium (PubChem CID ; 7849109) ; Paclitaxel (PubChem CID ; 36314) ; 5-Fluorouracil (PubChem CID ; 3385)
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：10 December 2016
- 年：2016
- 卷：239
- 期：Complete
- 页码：115-125
- 全文大小：1588 K
文摘
- 5">
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5">Dusquetide reduces the duration of mucositis in preclinical animal models.
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Dusquetide reduces the duration of oral mucositis in a Phase 2a clinical study.
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5">Preclinical models of mucositis were highly predictive of clinical results.
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Innate immune modulation is a successful strategy for mitigating mucositis.
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