Stereoselective synthesis of tetrahydrofurans: reactions of protected β-hydroxy ketones with benzyl diazoacetate

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• 作者：Angle ; Steven R. ; Chann ; Keith
• 关键词：tetrahydrofuran ; stereoselective synthesis ; ketone ; diazoester
• 刊名：Tetrahedron Letters
• 出版年：2001
• 出版时间：March 4, 2001
• 年：2001
• 卷：42
• 期：10
• 页码：1819-1822
• 全文大小：90.7 K

文摘

The stereoselective synthesis of 2,3,3,4-tetrasubstituted tetrahydrofurans from the Lewis acid catalyzed reaction of protected β-hydroxy ketones with benzyl diazoacetate is described. The reaction can be used to set three contiguous stereocenters including one that is a tertiary alcohol.