An immunoinhibition approach to overcome the impact of pre-existing antibodies on cut point establishment for immunogenicity assessment of moxetumomab pasudotox
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- 作者：Amy K. Schneider1 ; Inna Vainshtein ; 1 ; vainshteini@medimmune.com" class="auth_mail" title="E-mail the corresponding author ; Lorin K. Roskos ; Carlos Chavez ; Bo Sun ; Meina Liang ; liangm@medimmune.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cut point ; Pre-existing antibodies ; Biopharmaceuticals ; Anti-drug antibodies ; Immunogenicity ; Immunotoxin
- 刊名：Journal of Immunological Methods
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：435
- 期：Complete
- 页码：68-76
- 全文大小：1076 K
文摘
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Pre-existing antibodies interfere with immunogenicity assay cut point establishment.
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Immunoinhibition minimizes impact of pre-existing antibodies on cut point estimates.
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The method allows accurate immunogenicity assessment for moxetumomab pasudotox.
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