Evaluation of a candidate live attenuated influenza vaccine prepared in Changchun BCHT (China) for safety and efficacy in ferrets

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• 作者：Zhenwei Shen^b ; ¹ ; Richard A. Bowen^c ; Peng Ge^b ; Jinfei Yu^b ; Yanjie Shen^b ; Wei Kong^a ; Chunlai Jiang^a ; Jinchang Wu^a ; Changlin Zhu^b ; Yanjun Xu^b ; Wei Wei^b ; Larisa Rudenko^d ; Irina Kiseleva^d ; Fei Xu^a ; ^{feixu@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Influenza ; Trivalent live attenuated influenza vaccine ; Ferret
• 刊名：Vaccine
• 出版年：2016
• 出版时间：21 November 2016
• 年：2016
• 卷：34
• 期：48
• 页码：5953-5958
• 全文大小：891 K

文摘

We evaluated the safety and efficacy of a live attenuated influenza vaccine (LAIV) product in ferrets. The BCHT LAIV product was significantly less virulent than wild-type H1N1 virus, when evaluated by comparing virus shedding and histopathologic lesions. The data indicated strong evidence for an attenuated phenotype of LAIV. Furthermore, the vaccine induced robust humoral immune responses in seronegative ferrets, and protected ferrets against development of fever, weight loss and turbinate inflammatory lesions after challenging with H3N2 wide-type influenza virus. Thus, the BCHT LAIV product was safe in healthy seronegative ferrets and protected ferrets against infection of H3N2 influenza virus.