WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes
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- 作者：Gabriela David-Morrison1 ; 9 ; Zhen Xu2 ; 9 ; Yan-Ning Rui2 ; Wu-Lin Charng1 ; 3 ; Manish Jaiswal3 ; 4 ; Shinya Yamamoto1 ; 3 ; 5 ; Bo Xiong1 ; 10 ; Ke Zhang6 ; 11 ; Hector Sandoval3 ; Lita Duraine3 ; 4 ; Zhongyuan Zuo3 ; Sheng Zhang2 ; 7 ; 8 ; sheng.zhang@uth.tmc.edu" class="auth_mail" title="E-mail the corresponding author ; Hugo J. Bellen1 ; 3 ; 4 ; 5 ; 6 ; hbellen@bcm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Wacky ; Drosophila ; autophagy ; energy sensing ; neurodegeneration
- 刊名：Developmental Cell
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：36
- 期：2
- 页码：139-151
- 全文大小：5194 K
文摘
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Loss of Drosophila WAC homolog, Wacky, affects neuronal development and maintenance
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Wacky and WAC promote mTOR signaling in flies and human cells
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WAC promotes mTOR activation by mediating mTORC1 dimerization and Rag association
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WAC regulates energy-sensitive interaction between TTT and Pontin/Reptin complexes
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