Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives

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• 作者：Azas ; Nadine ; Rathelot ; Pascal ; Djekou ; Serge ; Delmas ; Florence ; Gellis ; A. ; Di Giorgio ; Carole ; et. al.
• 关键词：Antiparasitic activity ; Pyrimidine-2 ; 4-dione derivatives ; Toxicity ; THP1 cells ; Azomethines
• 刊名：Il Farmaco
• 出版年：2003
• 出版时间：December, 2003
• 年：2003
• 卷：58
• 期：12
• 页码：1263-1270
• 全文大小：396 K

文摘

4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl]benzaldehyde was synthesized in four steps from 6-methyl-1H,3H-pyrimidine-2,4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells.