Impact of mycotoxin on immune response and consequences for pig health

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• 作者：Alix Pierron^a ; ^b ; ^c ; Imourana Alassane-Kpembi^a ; ^b ; Isabelle P. Oswald^a ; ^b ; ^{isabelle.oswald@toulouse.inra.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Pig ; Mycotoxins ; Feed contamination ; Susceptibility to disease ; Immunity ; Vaccine efficacy
• 刊名：Animal Nutrition
• 出版年：2016
• 出版时间：June 2016
• 年：2016
• 卷：2
• 期：2
• 页码：63-68
• 全文大小：440 K

文摘

Mycotoxins are fungal secondary metabolites detected in many agricultural commodities, especially cereals. Due to their high consumption of cereals, pigs are exposed to these toxins. In the European Union, regulations and/or recommendations exist in pig feed for aflatoxins, ochratoxin A, fumonisins, zearalenone, and trichothecenes, deoxynivalenol and T-2 toxin. These mycotoxins have different toxic effects, but they all target the immune system. They have immunostimulatory or immunosuppressive effects depending on the toxin, the concentration and the parameter investigated. The immune system is primarily responsible for defense against invading organisms. The consequences of the ingestion of mycotoxin-contaminated feed are an increased susceptibility to infectious diseases, a reactivation of chronic infection and a decreased vaccine efficacy. In this review we summarized the data available on the effect of mycotoxins on the immune system and the consequences for pig health.