Novel miR-5582-5p functions as a tumor suppressor by inducing apoptosis and cell cycle arrest in cancer cells through direct targeting of GAB1, SHC1, and CDK2
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- 作者：Hyun-Ju Ana ; b ; Seo-Young Kwaka ; b ; Je-Ok Yooa ; Jae-Sung Kima ; In-Hwa Baea ; Myung-Jin Parka ; Mee-Yon Choc ; Joon Kimb ; Young-Hoon Hana ; yhhan@kirams.re.kr" class="auth_mail" title="E-mail the corresponding author ; yhhan33@hanmail.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：CRC ; colorectal cancer ; miRNA ; microRNA ; MTS ; (3-(4 ; 5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) ; GAB1 ; GRB2-associated binding protein 1 ; SHC1 ; SRC homology 2 domain containing 1 ; GRB2 ; growth factor receptor-bound protein 2 ; CDK2 ; cyclin-dependent kinase 2 ; SDS ; sodium dodecyl sulfate ; PAGE ; polyacrylamide gel electrophoresis ; FBS ; fetal bovine serum ; TUNEL ; terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling ; qRT-PCR ; quantitative rea
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：1862
- 期：10
- 页码：1926-1937
- 全文大小：1650 K
文摘
- 5">
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5">Novel miR-5582-5p was identified to induce apoptosis and cell cycle arrest in cancer cells.
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miR-5582-5p functions as a tumor suppressor in cancer cell-specific manner.
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5">miR-5582-5p expression is downregulated in tumor tissues compared to surrounding normal tissues.
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miR-5582-5p suppresses tumor growth in vivo.
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