Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling
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- 作者：Ye Caoa ; b ; c ; caoye1987122@163.com" class="auth_mail" title="E-mail the corresponding author ; Kai Guanc ; geminigk@aliyun.com" class="auth_mail" title="E-mail the corresponding author ; Xiang Hec ; hexiang_spring@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Congwen Weic ; weicw@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Zirui Zhengc ; zirui_zheng@163.com" class="auth_mail" title="E-mail the corresponding author ; Yanhong Zhangc ; yanhongzhang333@163.com" class="auth_mail" title="E-mail the corresponding author ; Shengli Maa ; b ; c ; shengli0128@163.com" class="auth_mail" title="E-mail the corresponding author ; Hui Zhongc ; towall@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Wei Shia ; b ; shiw@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BMDMs ; bone marrow-derived macrophages ; c-di-GMP ; cyclic diguanylate monophosphate ; DMEM ; Dulbecco's modified Eagle's medium ; ER ; endoplasmic reticulum ; FBS ; fetal bovine serum ; GST ; Glutathione S-transferase ; HEK293T ; human embryonic kidney ; IB ; immunoblotting ; IHC ; immunohistochemical ; K63 ; lysine 63 ; MAPK ; mitogen-activated protein kinase ; MAP2Ks ; mitogen-activated protein kinase kinases ; MAVS ; mitochondrial antiviral signaling protein ; M-CSF ; macrophage colony-stimulating factor ; NF-κB ; nucl
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：1863
- 期：12
- 页码：3148-3159
- 全文大小：1741 K
文摘
YopJ targets STING to inhibit IRF3 signaling.
YopJ interacts with STING to block its ER-to-Golgi traffic and remove its K63-linked ubiquitination chains.
The 172th cysteine of YopJ mediates STING deubiquitination and IRF3 signaling inhibition.
Mice infected with WT bacteria induced decreased inflammation and STING as compared to ΔYopJ and strains infection.
The data herein reveal a previously unrecognized mechanism by which YopJ modulates innate immune signaling.
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