Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins
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- 作者：Se-Jin Kima ; 1 ; Channy Parkb ; 1 ; Joon No Leea ; Hyewon Limc ; Gi-yeon Hongc ; Sung K. Moonb ; David J. Limb ; Seong-Kyu Choea ; 2 ; seongkyu642@wku.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Raekil Parka ; 2 ; rkpark@wku.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIF ; apoptosis-inducing factor ; Cisplatin ; cis-diammine-dichloroplatinum II ; Nrf2 ; NF-E2-related factor 2 ; OC ; organ of Corti ; PARP ; poly ADP ribose polymerase ; PUMA ; p53-upregulated modulator of apoptosis
- 刊名：Toxicology and Applied Pharmacology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：288
- 期：2
- 页码：192-202
- 全文大小：1316 K
文摘
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Erdosteine significantly attenuated cisplatin-induced cytotoxicity in HEI-OC1 cells.
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Erdosteine markedly increased the activation of PI3K/Akt pathway.
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Erdosteine induces the expression of Nrf2 and its target genes.
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Erdosteine significantly attenuated the accumulation of p53 in mitochondria.
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Erdosteine suppressed the release of AIF and cytochrome c from mitochondria.
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