Potential hepatic toxicity of buprofezin at sublethal concentrations: ROS-mediated conversion of energy metabolism
详细信息 查看全文
- 作者：Xiaotong Ji1 ; Tingting Ku1 ; Na Zhu ; Xia Ning ; Wei Wei ; Guangke Li ; Nan Sang ; sangnan@sxu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：TCA cycle ; tricarboxylic acid cycle ; ROS ; reactive oxygen species ; mtDNA ; mitochondrial DNA ; SCO1 ; cytochrome c oxidase assembly protein ; COX17 ; cytochrome c oxidase copper chaperone ; CS ; citrate synthase ; OGDH ; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) ; IDH2 ; isocitrate dehydrogenase 2 (NADP+) ; FH ; fumarase ; PFKFB3 ; 6-phosphofructo-2-kinase/fructose-2 ; 6-biphosphatase 3 ; LDHB ; lactate dehydrogenase B ; MMP ; mitochondrial membrane potential ; MRC ; mitochondrial respiratory chain
- 刊名：Journal of Hazardous Materials
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：320
- 期：Complete
- 页码：176-186
- 全文大小：3054 K
文摘
- •
Liver was one of the major organs for buprofezin accumulation and toxicity.
- •
Buprofezin promoted the shunting of energy metabolism.
- •
ROS participated in buprofezin-mediated cytochrome c oxidase inhibition.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |