Origin of Clostridium perfringens

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• 作者：Leen Timbermont ; Anouk Lanckriet ; Ahmad R. Gholami ; ehkordi ; Frank Pasmans ; An Martel ; Freddy Haesebrouck ; Richard Ducatelle ; Filip Van Immerseel
• 关键词：Clostridium perfringens ; Broilers ; In vivo ; Alpha toxin ; Host specificity
• 刊名：Comparative Immunology, Microbiology and Infectious Diseases
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：32
• 期：6
• 页码：503-512
• 全文大小：523 K

文摘

Since the ban on growth-promoting antibiotics in animal feed in the European Union, necrotic enteritis has become a major cause of mortality in broiler chickens. Despite the importance of the disease, the pathogenesis is still not completely understood. In the current study, Clostridium perfringens strains isolated from healthy flocks and isolates from outbreaks of necrotic enteritis were evaluated for the ability to cause gut necrosis in an intestinal loop model in laying hens and in an experimental infection model in broilers. High, intermediate and low alpha toxin producing strains were chosen from each isolation source. Only the isolates from field outbreaks induced necrotic gut lesions, independent of the amount of alpha toxin produced in vitro. It was also shown that alpha toxin producing isolates from calf hemorrhagic enteritis cases were not able to induce necrotic enteritis in poultry. These results suggest the presence of host specific virulence factors in C. perfringens strains, isolated from chickens with intestinal necrotic enteritis lesions.