Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
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- 作者：Wei-Chien Hung1 ; 2 ; 7 ; Jessica R. Yang3 ; 7 ; Christopher L. Yankaskas1 ; Bin Sheng Wong1 ; Pei-Hsun Wu1 ; 2 ; Carlos Pardo-Pastor6 ; Selma A. Serra6 ; Meng-Jung Chiang3 ; Zhizhan Gu1 ; Denis Wirtz1 ; 2 ; 5 ; Miguel A. Valverde6 ; Joy T. Yang4 ; jyang@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Jin Zhang3 ; jzhang32@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Konstantinos Konstantopoulos1 ; 2 ; 5 ; konstant@jhu.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：17 May 2016
- 年：2016
- 卷：15
- 期：7
- 页码：1430-1441
- 全文大小：3924 K
文摘
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Calcium is elevated via Piezo1 as cells transit from unconfined to confined spaces
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PKA activity is suppressed in confined relative to unconfined spaces
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Piezo1-dependent calcium increase negatively regulates PKA via PDE1 in confinement
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Piezo1/PDE1/PKA and myosin II independently mediate confinement sensing
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