miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle
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- 作者：Duo Zhang1 ; 14 ; Yan Li1 ; 14 ; Xuan Yao1 ; Hui Wang1 ; Lei Zhao2 ; Haowen Jiang3 ; Xiaohan Yao1 ; Shengjie Zhang1 ; Cheng Ye1 ; Wei Liu1 ; Hongchao Cao1 ; Shuxian Yu1 ; Yu-cheng Wang4 ; Qiong Li5 ; Jingjing Jiang6 ; Yi Liu7 ; Ling Zhang8 ; Yun Liu9 ; Naoharu Iwai10 ; Hui Wang1 ; 11 ; Jingya Li3 ; Jia Li3 ; Xihua Li2 ; Zi-Bing Jin12 ; 13 ; jinzb@mail.eye.ac.cn" class="auth_mail" title="E-mail the corresponding author ; Hao Ying1 ; 4 ; 11 ; yinghao@sibs.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：19 July 2016
- 年：2016
- 卷：16
- 期：3
- 页码：757-768
- 全文大小：4644 K
文摘
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miR-182 is enriched in fast muscle, and its level correlates with blood glucose level
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Loss of miR-182 leads to muscle fiber-type switching and impaired glucose metabolism
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miR-182 regulates glucose utilization by modulating PDHC activity via FoxO1/PDK4
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Restoration of miR-182 expression improves glucose metabolism in mice fed a high-fat diet-fed
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