One pot Click chemistry: A three component reaction for the synthesis of 2-mercaptobenzimidazole linked coumarinyl triazoles as anti-tubercular agents
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- 作者：Ashish Ananda ; Manohar V. Kulkarnia ; manohar274@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Shrinivas D. Joshib ; Sheshagiri R. Dixitb
- 关键词：1 ; 2 ; 3-Triazoles ; One pot Click reaction ; 2H-Chromen-2-one ; 2-Mercaptobenzimidazole ; Anti-tubercular ; Molecular docking ; Surflex-Dock
- 刊名：Bioorganic & Medicinal Chemistry Letters
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：26
- 期：19
- 页码：4709-4713
- 全文大小：1641 K
文摘
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One pot synthesis and characterization of mercapto-coumarinyl triazoles.
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Formation of 1,4 isomer under Cu(I) Click conditions.
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Anti-tubercular results for the 1,4 disubstituted triazole were good–excellent.
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Docking studies revealed effect of mercaptobenzimidazole in the binding ability.
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