A novel sandwiched electrochemiluminescence immunosensor for the detection of carcinoembryonic antigen based on carbon quantum dots and signal amplification
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- 作者：Nian-Lu Li ; Li-Ping Jia ; Rong-Na Ma ; Wen-Li Jia ; Yi-Yang Lu ; Sha-Shan Shi ; Huai-Sheng Wang ; hswang@lcu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Electrochemiluminescence immunosensor ; Carcinoembryonic antigen ; Carbon quantum dots ; Functionalized graphene oxide
- 刊名：Biosensors and Bioelectronics
- 出版年：2017
- 出版时间：15 March 2017
- 年：2017
- 卷：89
- 期：part_P1
- 页码：453-460
- 全文大小：261 K
文摘
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The nanocomposite of polydopamine and Ag nanoparticles (PDA-AgNPs) provided an effective matrix for the immobilization of primary antibody (Ab1).
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Carbon quantum dots (CQDs), the electrochemiluminescence material, were immobilized on the poly(ethylenimine) functionalized graphene oxide (PEI-GO) to link secondary antibody (Ab2).
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The ECL signals of CQDs were greatly amplified under the synergistic effect of AgNPs, polydopamine, AuNPs and PEI-GO.
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The proposed ECL immunosensor can be used for the detection of CEA in real human serum samples.
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