CD40 signaling activated by Epstein–Barr virus promotes cell survival and proliferation in gastric carcinoma-derived human epithelial cells

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• 作者：Ken-Ichi Imadome ; Norio Shimizu ; Misako Yajima ; Ken Watanabe ; Hiroyuki Nakamura ; Hiroaki Takeuchi ; Shigeyoshi Fujiwara
• 关键词：Epstein– ; Barr virus ; CD40 ; CD40L ; Epithelial cell ; Apoptosis ; Proliferation
• 刊名：Microbes and Infection
• 出版年：2009
• 出版时间：March 2009
• 年：2009
• 卷：11
• 期：3
• 页码：429-433
• 全文大小：293 K

文摘

CD40 signaling plays a critical role in the survival and proliferation of EBV-infected lymphocytes. Here we show that CD40 is constitutively expressed in the human gastric carcinoma-derived cell lines AGS, MKN28, and MKN74, and expression of CD40L is induced by in vitro infection with EBV. Blocking the interaction between CD40 and CD40L with CD40Ig, a fusion protein of CD40 and IgG, impaired proliferation of EBV-infected AGS cells and enhanced their calcium ionophore-induced apoptosis. These results suggest that CD40 signaling plays a critical role in the survival and proliferation of EBV-infected epithelial cells, as well as in the virus-infected lymphocytes.