Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate
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- 作者：Jun Zhoua ; Xiang Fanga ; fangxiang@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Tongle Shaoa ; Xueyan Yanga ; yxy@ecust.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Fanhong Wua ; b
- 关键词：Palladium-catalyzed reaction ; Mono-α-arylation ; α-Aryl-α-fluoroketones
- 刊名：Journal of Fluorine Chemistry
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：191
- 期：Complete
- 页码：54-62
- 全文大小：1229 K
文摘
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Palladium catalyzed Nigishi-type α-arylation of α-fluoroketones with a broad range of aryl halides or phenyl triflate.
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Pd(OAc)2 as catalyst, Xphos as ligand and Cs2CO3 as mild base play the important role.
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The desired monoarylated α-fluoroketones were obtained in good yields.
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A practical synthetic strategy to potentially bioactive fluorocarbonyl compounds.
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