Characterization of magnetite nanoparticles for SQUID-relaxometry and magnetic needle biopsy

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• 作者：Natalie L. Adolphi ; Dale L. Huber ; Jason E. Jaetao ; Howard C. Bryant ; Debbie M. Lovato ; Danielle L. Fegan ; Eugene L. Venturini ; Todd C. Monson ; Trace E. Tessier ; Helen J. Hathaway ; Christian Bergemann
• 关键词：Magnetite ; Nanoparticle ; Magnetorelaxometry ; SQUID detection ; Susceptometry ; Antibody-conjugation
• 刊名：Journal of Magnetism and Magnetic Materials
• 出版年：2009
• 出版时间：May 2009
• 年：2009
• 卷：321
• 期：10
• 页码：1459-1464
• 全文大小：710 K

文摘

Magnetite nanoparticles (Chemicell SiMAG-TCL) were characterized by SQUID-relaxometry, susceptometry, and TEM. The magnetization detected by SQUID-relaxometry was 0.33 % of that detected by susceptometry, indicating that the sensitivity of SQUID-relaxometry could be significantly increased through improved control of nanoparticle size. The relaxometry data were analyzed by the moment superposition model (MSM) to determine the distribution of nanoparticle moments. Analysis of the binding of CD34-conjugated nanoparticles to U937 leukemia cells revealed 60,000 nanoparticles per cell, which were collected from whole blood using a prototype magnetic biopsy needle, with a capture efficiency of >65 % from a 750 ;c;l sample volume in 1 min.