Regulation of GABA_A receptor membrane trafficking and synaptic localization

详细信息    查看全文

• 作者：I. Lorena Arancibia-Cá ; rcamo ; Josef T. Kittler
• 关键词：Endocytosis ; Epilepsy ; Phosphorylation ; Ubiquitination ; Palmitoylation ; Inhibition
• 刊名：Pharmacology and Therapeutics
• 出版年：2009
• 出版时间：July 2009
• 年：2009
• 卷：123
• 期：1
• 页码：17-31
• 全文大小：1032 K

文摘

Synaptic inhibition plays a key role in regulating neuronal excitability and information processing in the brain. The strength of synaptic inhibition is therefore an important determinant of both cellular and network activity levels in the central nervous system (CNS). γ-aminobutyric acid type A (GABA_A) receptors are the major sites for fast inhibitory neurotransmission in the CNS and alterations in their trafficking, synaptic accumulation and function play a key role in regulating neuronal excitability. Synaptic receptor number is determined by the trafficking of GABA_A receptors to and away from inhibitory synapses and by their stability and localization at the inhibitory postsynaptic domain. Here we discuss advances that have led to an improved understanding of the mechanisms that regulate the delivery and stabilization of GABA_A receptors at inhibitory synapses and address the role of GABA_A receptor trafficking, GABA_A receptor associated proteins and post-translational modifications in regulating this process.