Relative effect potency estimates of dioxin-like activity for dioxins, furans, and dioxin-like PCBs in adults based on cytochrome P450 1A1 and 1B1 gene expression in blood
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- 作者：Soňa Wimmerová ; a ; sona.wimmerova@szu.sk" class="auth_mail" title="E-mail the corresponding author ; Martin van den Bergb ; m.vandenberg@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Jana Chovancová ; a ; jana.chovancova@szu.sk" class="auth_mail" title="E-mail the corresponding author ; Henrieta Patayová ; a ; henrieta.patayova@szu.sk" class="auth_mail" title="E-mail the corresponding author ; Todd A. Juskoc ; todd_jusko@urmc.rochester.edu" class="auth_mail" title="E-mail the corresponding author ; Majorie B.M. van Duursenb ; m.vanduursen@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Ľubica Palkovičová ; Murí ; nová ; a ; lubica.murinova@szu.sk" class="auth_mail" title="E-mail the corresponding author ; Rocio F. Cantonb ; rfcanton@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Karin I. van Edeb ; K.I.vanEde@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Tomá ; &scaron ; Trnoveca ; tomas.trnovec@szu.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dioxin-like polychlorinated biphenyl (DL-PCB) ; Polychlorinated dibenzo-p-dioxins (PCDDs) ; Polychlorinated dibenzo-p-furans (PCDFs) ; Relative effect potency (REP) ; Toxic equivalency factor (TEF) ; Cytochrome P450 (CYP) 1A1 and 1B1
- 刊名：Environment International
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：24-33
- 全文大小：905 K
文摘
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TEFs for assessment of health risks from dioxin-like compounds are regularly updated.
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Besides TEFs based on animal studies, we derived REPs based on human health outcomes.
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We used thyroid and cytochrome P450 (CYP) 1A1 and 1B1 gene expression endpoints in PBMC of exposed adults.
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REPs from CYP1A1 correlated with REPs derived from thyroid volume and serum FT4 outcomes.
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REPs based on chronic, low-dose exposure sustain validity of dioxin TEFs and reflect most human exposure scenarios.
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