Shorter sperm telomere length in association with exposure to polycyclic aromatic hydrocarbons: Results from the MARHCS cohort study in Chongqing, China and in vivo animal experiments
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- 作者：Xi Ling ; Guowei Zhang ; Qing Chen ; Huan Yang ; Lei Sun ; Niya Zhou ; Zhi Wang ; Peng Zou ; Xiaogang Wang ; Zhihong Cui ; Jinyi Liu ; Lin Ao ; aolin117@163.com" class="auth_mail" title="E-mail the corresponding author ; Jia Cao ; caojia1962@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MARHCS ; the Male Reproductive Health in Chongqing College Students ; PAHs ; polycyclic aromatic hydrocarbons ; B[a]P ; benzo[a]pyrene ; STL ; sperm telomere length ; 1-OHNap ; 1-hydroxynaphthalene ; 2-OHNap ; 2-hydroxynaphthalene ; 2-OHFlu ; 2-hydroxyfluorene ; 1-OHPhe ; 1-hydroxyphenanthrene ; 2-OHPhe ; 2-hydroxyphenanthrene ; 3-OHPhe ; 3-hydroxyphenanthrene ; 4-OHPhe ; 4-hydroxyphenanthrene ; 1-OHPyr ; 1-hydroxypyrene
- 刊名：Environment International
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：79-85
- 全文大小：361 K
文摘
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We measured eight urinary PAH metabolites as exposure markers.
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Associations of urinary PAH metabolites with semen quality, sperm apoptosis and STL were assessed in college students.
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Urinary 1-OHPyr and 1-OHNap were negatively associated with STL.
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No significant associations between urinary PAH metabolites and semen quality or sperm apoptosis were found.
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B[a]P shortened STL and decreased the telomerase expression in germ cells in vivo animal experiments.
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