Interplay of the intramolecular N–H···N bond and π-stacking interaction in 2-(2’-tosylaminophenyl)benzimidazoles

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• 作者：Konstantin A. Lyssenko ; Alex ; ra O. Borissova ; Anatolii S. Burlov ; Igor S. Vasilchenko ; Alex ; er D. Garnovskii ; Vladimir I. Minkin ; Mikhail Yu. Antipina
• 关键词：cadmium ; zinc ; genotoxicity ; V79 cells ; micronucleus test
• 刊名：Mendeleev Communications
• 出版年：2007
• 出版时间：May-June 2007
• 年：2007
• 卷：17
• 期：3
• 页码：164-166
• 全文大小：526 K

文摘

The induction of micronuclei (MN) in mitotically active cells has been widely used and promoted as a biological marker of exposure to environmental toxins. In our study the effect of zinc on cadmium genotoxicity was investigated in V 79 cells. The results indicate that cadmium chloride exposure for 24 h increased micronucleus frequency and the percentage of binucleated cells in dose-dependent manner. At the highest concentration of cadmium (50 μM Cd) 23 MN were found in 1000 cells. The protective effect of zinc on cadmium genotoxicity was investigated at lower concentrations (5–25 μM CdCl<sub>2sub>). At 50 μM Cd, the number of MN increased significantly (16 MN).