Functional brain network changes associated with clinical and biochemical measures of the severity of hepatic encephalopathy
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- 作者：Tun Jaoa ; b ; Manuel Schrö ; tera ; Chao-Long Chenc ; Yu-Fan Chengd ; Chun-Yi Zac Loe ; f ; Kun-Hsien Choue ; f ; Ameera X. Patela ; Wei-Che Lind ; u64lin@yahoo.com.tw" class="auth_mail" title="E-mail the corresponding author ; Ching-Po Line ; f ; cplin@ym.edu.tw" class="auth_mail" title="E-mail the corresponding author ; Edward T. Bullmorea ; g ; h
- 关键词：Consciousness ; Brain networks ; Hepatic encephalopathy ; Liver cirrhosis ; Resting-state fMRI
- 刊名：NeuroImage
- 出版年：2015
- 出版时间：15 November 2015
- 年：2015
- 卷：122
- 期：Complete
- 页码：332-344
- 全文大小：2200 K
文摘
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We studied effects of various degrees of hepatic encephalopathy (HE) on rs-fMRI.
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Decrease of clustering and modularity of networks happened even before minimal HE.
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Since minimal HE ammonia increased with nonlinear decay of connectivity strength.
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Since overt HE there was extensive topological and spatial network reorganization.
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We provide novel and complementary biomarkers of HE diagnosis and follow-up.
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