Cereboost™, an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection
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- 作者：Kyungha Shina ; 1 ; Haiyu Guoa ; 1 ; Yeseul Chaa ; Young-Hwan Bana ; Da Woom Seoa ; Youngjin Choia ; Tae-Su Kimb ; Sung-Pyo Leeb ; Jong-Choon Kimc ; Ehn-Kyoung Choia ; Jung-Min Yona ; yjm0000@hanmail.net" class="auth_mail" title="E-mail the corresponding author ; Yun-Bae Kima ; solar93@cbu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Amyloid-beta peptide ; Cognitive function ; Cereboost&trade ; American ginseng (Panax quinquefolius) ; Choline acetyltransferase ; Neuroprotection
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：53-58
- 全文大小：819 K
文摘
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Cognition-enhancing effects of Cereboot™, an American ginseng extract, were investigated.
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Cereboot™ inhibited Aβ cytotoxicity and enhanced ChAT expression in F3.ChAT cells.
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Cereboot™ recovered cognitive function of Aβ1-42-challenged mice.
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Neuronal integrity and acetylcholine level were restored by treatment with Cereboot™.
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