Possible involvement of hippocampal immediate-early genes in contextual fear memory deficit induced by cranial irradiation
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- 作者：Yeonghoon Sona ; 1 ; Sohi Kanga ; 1 ; Jinwook Kima ; Sueun Leea ; Jong-Choon Kima ; Sung-Ho Kima ; Joong-Sun Kimb ; Sung-Kee Joc ; Uhee Jungc ; BuHyun Yound ; Taekyun Shine ; Miyoung Yangf ; yangm@wku.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Changjong Moona ; moonc@chonnam.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Arc ; Cranial irradiation ; c-fos ; Hippocampus ; Memory deficit ; zif268
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：133
- 期：Complete
- 页码：19-29
- 全文大小：2154 K
文摘
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Cranial irradiation impaired hippocampus-related memory.
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Immediate–early genes (IEGs) are implicated in memory formation in the hippocampus.
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Irradiation inhibited the induction of hippocampal IEGs via behavioral contextual fear memory.
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The disturbance in the induction of IEGs may be related to radiation-induced memory deficits.
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