Rapid chain generation of interpostsynaptic functional LINKs can trigger seizure generation: Evidence for potential interconnections from pathology to behavior
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- 作者：Kunjumon I. Vadakkan kunjumon.vadakkan@utoronto.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ; dendritic spine ; spine or postsynaptic terminal or postsynapse ; DHA ; docosahexaenoic acid ; ECM ; extracellular matrix ; EEG ; electroencephalogram ; EPSP ; excitatory postsynaptic potential ; GABA ; gamma-aminobutyric acid ; GluA1 ; AMPA receptor subunit A1 ; HCN ; hyperpolarization-activated cyclic nucleotide-gated ; IPL ; interpostsynaptic functional LINK or LINK ; islet ; islet of inter-LINKed postsynaptic terminals ; LC-PUFA ; long chain polyunsatur
- 刊名：Epilepsy & Behavior
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：59
- 期：Complete
- 页码：28-41
- 全文大小：1829 K
文摘
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Provides a mechanism for rapid spread of seizure activity
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Provides an interconnected mechanism for hallucinations, cognitive impairment, and neurodegenerative changes
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Explains similarity between kindling and rapid spread of seizure activity
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Provides a cellular mechanism for paroxysmal depolarization shift
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Provides a potential additional mechanism for ketogenic diet
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