Electrochemiluminescence immunosensor for sensitive determination of tumor biomarker CEA based on multifunctionalized Flower-like Au@BSA nanoparticles
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- 作者：Amin ZhangaAuthor Vitae ; Chusen HuangaAuthor Vitae ; Hongyuan ShibAuthor Vitae ; Weiwei GuoaAuthor Vitae ; Xin ZhangaAuthor Vitae ; Hongkun XiangaAuthor Vitae ; Ti JiaaAuthor Vitae ; Fei MiaobAuthor Vitae ; Nengqin Jiaa ; nqjia@shnu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Electrochemiluminescence ; Immunosensor ; Carcinoembryonic antigen ; Luminol ; Flower-like Au@BSA core/shell nanoparticles
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：238
- 期：Complete
- 页码：24-31
- 全文大小：2465 K
文摘
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A Flower-Like Au@BSA nanoparticles-based ECL immunosensor for ultrasensitive determination of CEA was constructed.
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Enhanced ECL signal of the immunosensor could be achieved by synergistic amplification strategy of using DpAu and Au@BSA.
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The immunosensor could sensitively detect antigen CEA based on the decrease of ECL intensity of luminol.
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The proposed ECL immunosensor exhibited high assay performances in reproducibility, stability and specificity.
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