Highly selective detection of disulfenylated proteins through a dimedone-based fluorescent probe and application in cells
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- 作者：Ting-Xiang Liu1Author Vitae ; Li Zhang1Author Vitae ; Ru-Ping Liang ; rpliang@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Jian-Ding Qiu ; jdqiu@ncu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Disulfenylation ; Thioredoxin ; Dimedone ; Fluorescent ; In cells
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：238
- 期：Complete
- 页码：257-263
- 全文大小：2218 K
文摘
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A novel probe TAR has been synthesized.
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A pyrene-mediated turn-on fluorescent sensor for thioredoxin disulfenylation has been proposed.
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Thioredoxin preference of TAR has been proved by fluorometric and cell imaging experiments.
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Thioredoxin activity can be detected at nanomolar concentrations.
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