Breast cancer-secreted miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers
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- 作者：Martina Di Modicaa ; Viola Regondia ; Marco Sandria ; Marilena V. Ioriob ; Adriana Zanettic ; Elda Tagliabuea ; elda.tagliabue@istitutotumori.mi.it" class="auth_mail" title="E-mail the corresponding author ; Patrizia Casalinia ; 1 ; Tiziana Triulzia ; 1
- 关键词：Breast cancer ; Triple-negative breast cancer ; miR-939 ; Exosomes ; Metastasis
- 刊名：Cancer Letters
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：384
- 期：Complete
- 页码：94-100
- 全文大小：1113 K
文摘
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A new role for miR-939 in breast cancer is proposed.
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miR-939 interaction with lymph node status predicts worse prognosis in TNBCs.
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miR-939 is released in exosomes and regulates VE-cadherin in endothelial cells.
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Down modulation of VE-cadherin enhances cancer cells trans-endothelial migration.
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