Aromatase inhibitors in premenopause: Great expectations fulfilled?
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- 作者：Rosalba Torrisi ; MDa ; 1 ; rosalba.torrisi@humanitas.it" class="auth_mail" title="E-mail the corresponding author ; Selene Rota ; MDa ; selene.rota@humanitas.it" class="auth_mail" title="E-mail the corresponding author ; Agnese Losurdo ; MDa ; agnese.losurdo@humanitas.it" class="auth_mail" title="E-mail the corresponding author ; Monica Zuradelli ; MDa ; monica.zuradelli@humanitas.it" class="auth_mail" title="E-mail the corresponding author ; Giovanna Masci ; MDa ; giovanna.masci@humanitas.it" class="auth_mail" title="E-mail the corresponding author ; Armando Santoro ; MDb ; armando.santoro@humanitas.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aromatase inhibitors ; Premenopause ; Breast cancer ; Ovarian suppression ; Circulating estradiol
- 刊名：Critical Reviews in Oncology and Hematology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：107
- 期：Complete
- 页码：82-89
- 全文大小：652 K
文摘
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Aromatase inhibitors plus GnRH a are active in HR +ve premenopausal breast cancer.
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Adjuvant exemestane clearly outperforms tamoxifen in high-risk and young women.
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Degree of ovarian suppression may be crucial for aromatase inhibitors activity.
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Monitoring estradiol upon AI therapy may be useful in young chemotherapy-naïve women.
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