Identification and bioactivity evaluation of two novel temporins from the skin secretion of the European edible frog, Pelophylax kl. esculentus
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- 作者：Xiaole Chena ; leochen5139@fjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; He Wangb ; hwang11@qub.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Mu Yangc ; Lei Wangc ; Mei Zhouc ; Tianbao Chenc ; Chris Shawc
- 关键词：Amphibian ; Antimicrobial peptide ; Temporins ; Molecular cloning
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：5 August 2016
- 年：2016
- 卷：476
- 期：4
- 页码：566-573
- 全文大小：1452 K
文摘
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Two novel temporins were isolated and identified from the amphibian skin secretion.
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Temporine-1Ee display rarely active against both Gram-positive and Gram-negative bacteria compared with most temporins.
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Single-site substitutions can dramatically change the spectrum of activity of a given temporin.
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