miR-18a promotes cell proliferation of esophageal squamous cell carcinoma cells by increasing cylin D1 via regulating PTEN-PI3K-AKT-mTOR signaling axis
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- 作者：Weiguo Zhang ; weiguozhangHU@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Caipeng Lei ; Junli Fan ; Jing Wang
- 关键词：miR-18a ; PTEN ; Esophageal squamous cell carcinoma ; Cyclin D1 ; Cell proliferation ; Cell cycle
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：12 August 2016
- 年：2016
- 卷：477
- 期：1
- 页码：144-149
- 全文大小：864 K
文摘
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miR-18a promotes the proliferation of ESCC cells.
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miR-18a increase cyclin D1 expression in ESCC cells.
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miR-18a directly targets PTEN in ESCC cells.
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Inhibition of AKT-mTOR prevents miR-18a-induced cyclin D1 in ESCC cells.
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miR-18a antagomir sensitizes ESCC cells to cisplatin.
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