Limited diagnostic value of Dual-Time-Point ¹⁸F-FDG PET/CT imaging for classifying solitary pulmonary nodules in granuloma-endemic regions both at visual and quantitative analyses

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• 作者：Song Chen ^{chensongchina@163.com" class="auth_mail" title="E-mail the corresponding author} ; Xuena Li ^{lixuenacmunm@163.com" class="auth_mail" title="E-mail the corresponding author} ; Meijie Chen ^{chenmj2015@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Yafu Yin ^{yinyf-2001@163.com" class="auth_mail" title="E-mail the corresponding author} ; Na Li ^{anna_lee2011@163.com" class="auth_mail" title="E-mail the corresponding author} ; Yaming Li ; ^{ymli2001@163.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：SPN ; solitary pulmonary nodule ; STPI ; single time point imaging ; DTPI ; dual time point imaging ; RI ; retention index ; AUC ; areas under curve
• 刊名：European Journal of Radiology
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：85
• 期：10
• 页码：1744-1749
• 全文大小：617 K

文摘

This study is aimed to compare the diagnostic power of using quantitative analysis or visual analysis with single time point imaging (STPI) PET/CT and dual time point imaging (DTPI) PET/CT for the classification of solitary pulmonary nodules (SPN) lesions in granuloma-endemic regions.

Methods

SPN patients who received early and delayed ¹⁸F-FDG PET/CT at 60 min and 180 min post-injection were retrospectively reviewed. Diagnoses are confirmed by pathological results or follow-ups. Three quantitative metrics, early SUV_max, delayed SUV_max and retention index(the percentage changes between the early SUV_max and delayed SUV_max), were measured for each lesion. Three 5-point scale score was given by blinded interpretations performed by physicians based on STPI PET/CT images, DTPI PET/CT images and CT images, respectively. ROC analysis was performed on three quantitative metrics and three visual interpretation scores.

Result

One-hundred-forty-nine patients were retrospectively included. The areas under curve (AUC) of the ROC curves of early SUV_max, delayed SUV_max, RI, STPI PET/CT score, DTPI PET/CT score and CT score are 0.73, 0.74, 0.61, 0.77 0.75 and 0.76, respectively. There were no significant differences between the AUCs in visual interpretation of STPI PET/CT images and DTPI PET/CT images, nor in early SUVmax and delayed SUV_max. The differences of sensitivity, specificity and accuracy between STPI PET/CT and DTPI PET/CT were not significantly different in either quantitative analysis or visual interpretation.

Conclusion

In granuloma-endemic regions, DTPI PET/CT did not offer significant improvement over STPI PET/CT in differentiating malignant SPNs in both quantitative analysis and visual interpretation.