A bispecific anti-ErbB2 antibody potently induces ErbB2 internalization and suppresses ErbB2-overexpressing tumor growth
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- 作者：Yajun Zhanga ; 1 ; Lingfei Wanga ; 1 ; Xiaodan Chonga ; 1 ; Xiaojie Yua ; 1 ; Yanchun Mengb ; Jian Dongc ; Chao Wanga ; Huajing Wanga ; Yang Yanga ; Tian Xiaa ; Jian Zhaoa ; Bohua Lia ; bohuali1020@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：ErbB2 ; Monoclonal antibody ; Down-regulation ; Bispecific antibody ; Gastric cancer
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：477
- 期：4
- 页码：755-760
- 全文大小：1935 K
文摘
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Not all of the non-competitive anti-ErbB2 mAb pairs induce ErbB2 internalization.
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A bispecific antibody was engineered from two non-competitive anti-ErbB2 mAbs.
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This bispecific antibody shows enhanced ErbB2 internalization-inducing ability.
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This bispecific antbody exhibits extremely potent antitumor activity.
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