Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells
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- 作者：Yichu Niea ; b ; 1 ; Chuqin Huanga ; 1 ; Shan Zhonga ; Michael A. Wortleyb ; Yulong Luoa ; Wei Luoa ; Yanqing Xiea ; Kefang Laia ; klai@163.com" class="auth_mail" title="E-mail the corresponding author ; Nanshan Zhonga
- 关键词：Cigarette smoke extract (CSE) ; Transient receptor potential ankyrin repeat 1 ; Hypoxia-inducible factor-1α ; Nuclear factor-κ B ; Histone deacetylase 2
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：498-507
- 全文大小：2878 K
文摘
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CSE induces TRPA1 hyper-expression in A549, 16HBE, and BEAS-2B cells.
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CSE-induced TRPA1 expression is directly mediated by HIF1α, but not by NF-κ B.
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NF-κ B indirectly regulates TRPA1 expression by modulating HIF1α mRNA transcription.
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HDAC2 indirectly modulates TRPA1 expression by promoting DNA-binding of HIF1α.
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