Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation
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- 作者：Andrea Di Francescoa ; Clara Di Germanioa ; Amaresh C. Pandab ; Phu Huynha ; Robert Peadena ; Ignacio Navas-Enamoradoa ; Paul Bastianb ; Elin Lehrmannb ; Alberto Diaz-Ruiza ; David Rossc ; David Siegelc ; Jennifer L. Martindaleb ; Michel Berniera ; Myriam Gorospeb ; Kotb Abdelmohsenb ; abdelmohsenk@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Rafael de Caboa ; deCaboRa@grc.nia.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARE ; antioxidant response elements ; A1AT ; α-1-antitrypsin ; COPD ; chronic obstructive pulmonary disease ; CR ; coding region ; FL ; firefly luciferase ; GRB ; growth factor receptor-bound protein ; IP ; immunoprecipitation ; Keap1 ; Kelch-like ECH-associated protein 1 ; KLHL ; Kelch-like family member 7 ; Nrf2 ; nuclear factor erythroid 2-related factor ; NQO1 ; NAD(P)H ; quinone oxidoreductase 1 ; qPCR ; quantitative real-time polymerase chain reaction ; RBP ; RNA-binding protein ; RIP ; ribonucleoprotein immunoprecipi
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：225-233
- 全文大小：2185 K
文摘
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NQO1 is a novel RNA-binding protein.
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10">Binding of NQO1 to SERPINA1 mRNA enhances translation of the encoded protein, A1AT.
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15">NQO1-KO mice have reduced A1AT levels and increased neutrophil elastase activity.
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