miR-34a and its novel target, NLRC5, are associated with HPV16 persistence
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- 作者：Jinyuan Lia ; 1 ; Libo Yub ; 1 ; Zhenji Shena ; Yushu Lic ; Beibei Chenb ; Wei Weid ; Xiaohang Chena ; Qingyi Wange ; Fangjia Tonga ; Huihuang Loua ; Ming Chuc ; Lanlan Weia ; weilanlan_1119@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Human papillomavirus type 16 ; persistent infection ; Cervical cancer ; miR-34a ; NLRC5 ; p65
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：44
- 期：Complete
- 页码：293-299
- 全文大小：827 K
文摘
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miR-34a and NLRC5 are associated with HPV16 persistence.
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NLRC5 interacts with miR-34a.
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Upregulation of NLRC5 is concurrent with downregulation of miR-34a in human cervical samples with HPV16 persistence.
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Our data uncover a previously unknown connection between the HPV16 persistence and miR-34a which directly targets to NLRC5.
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The reverse expression pattern of NLRC5 and miR-34a might be involved in the interference of HPV16 with host defense system.
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