Associations between branched chain amino acid intake and biomarkers of adiposity and cardiometabolic health independent of genetic factors: A twin study

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• 作者：Amy Jennings^a ; ¹ ; Alex MacGregor^a ; ¹ ; Tess Pallister^b ; ¹ ; Tim Spector^b ; ¹ ; Aedí ; n Cassidy^a ; ¹ ; ^{a.cassidy@uea.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：BCAA ; branched chain amino acids ; DBP ; diastolic blood pressure ; DZ ; dizygotic ; FFQ ; food frequency questionnaire ; HDL-C ; high density lipoprotein cholesterol ; hs-CRP ; high sensitivity C-reactive protein ; MZ ; monozygotic ; SBP ; systolic blood pressure ; T2DM ; type 2 diabetes ; SBP ; systolic blood pressure ; WHtR ; waist to height ratio
• 刊名：International Journal of Cardiology
• 出版年：2016
• 出版时间：15 November 2016
• 年：2016
• 卷：223
• 期：Complete
• 页码：992-998
• 全文大小：342 K

文摘

Conflicting data exist on the impact of dietary and circulating levels of branched chain amino acids (BCAA) on cardiometabolic health and it is unclear to what extent these relations are mediated by genetics.

Methods

In a cross-sectional study of 1997 female twins we examined associations between BCAA intake, measured using food frequency-questionnaires, and a range of markers of cardiometabolic health, including DXA-measured body fat, blood pressure, HOMA-IR, high-sensitivity C-reactive protein (hs-CRP) and lipids. We also measured plasma concentrations of BCAA and known metabolites of amino acid metabolism using untargeted mass spectrometry. Using a within-twin design, multivariable analyses were used to compare the associations between BCAA intake and endpoints of cardiometabolic health, independently of genetic confounding.

Results

Higher BCAA intake was significantly associated with lower HOMA-IR (− 0.1, P-trend 0.02), insulin (− 0.5 μU/mL, P-trend 0.03), hs-CRP − 0.3 mg/L, P-trend 0.01), systolic blood pressure (− 2.3 mmHg, P-trend 0.01) and waist-to-height ratio (− 0.01, P-trend 0.04), comparing extreme quintiles of intake. These associations persisted in within-pair analysis for monozygotic twins for insulin resistance (P < 0.01), inflammation (P = 0.03), and blood pressure (P = 0.04) suggesting independence from genetic confounding. There was no association between BCAA intake and plasma concentrations, although two metabolites previously associated with obesity were inversely associated with BCAA intake (alpha-hydroxyisovalerate and trans-4-hydroxyproline).

Conclusions

Higher intakes of BCAA were associated, independently of genetics, with lower insulin resistance, inflammation, blood pressure and adiposity-related metabolites. The BCAA intake associated with our findings is easily achievable in the habitual diet.