Long-term safety and tolerability of asenapine: A double-blind, uncontrolled, long-term extension trial in adults with an acute manic or mixed episode associated with bipolar I disorder
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- 作者：Terence A. Kettera ; tketter@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Suresh Durgamb ; Ronald Landbloomc ; Mary Macklec ; Xiao Wub ; Maju Mathewsd
- 关键词：Bipolar disorder ; Mania ; Mixed episodes ; Asenapine ; Safety ; Tolerability
- 刊名：Journal of Affective Disorders
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：207
- 期：Complete
- 页码：384-392
- 全文大小：755 K
文摘
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Asenapine 5 and 10 mg bid was generally safe and well tolerated up to 29 weeks.
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The metabolic effects of ASN appear consistent with previous studies.
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No dose dependence for predefined treatment-emergent adverse events.
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Serious adverse events primarily due to underlying bipolar I disorder.
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