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Neurotoxic phospholipase Ab>2b> from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus)
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文摘
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CB, the PLAb>2b> subunit of crotoxin is a new ligand and allosteric modulator of GLIC.

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GLIC, a proton-gated ion channel is a new protein target of CB.

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The PLAb>2b>-GLIC interaction involves the ECD of GLIC.

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The enzymatic activity of PLAb>2b> is enhanced by its interaction with GLIC.

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