Radioligand binding assay for accurate determination of nuclear retinoid X receptors: A case of triorganotin endocrine disrupting ligands
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- 作者：Lucia Toporova ; Dana Macejova ; Julius Brtko ; julius.brtko@savba.sk" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATRA ; all-trans retinoic acid ; Bmax ; maximal binding capacity (pmol/mg) ; DNA ; deoxyribonucleic acid ; DR ; direct repeat ; DTT ; 1 ; 4-dithiothreitol ; FXR ; farnesoid X receptor ; Ka ; affinity (l/mol) ; LBD ; ligand-binding domain ; LXR ; liver X receptor ; PMSF ; phenylmethylsulfonyl fluoride ; PPAR ; peroxisome proliferator activated receptor ; PXR ; pregnane X receptor ; RAR ; retinoid receptor ; RARE ; retinoid response element ; RXR ; retinoid X receptor (rexinoid receptor) ; RXRE ; retinoid X response element ; TBT-
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：8 July 2016
- 年：2016
- 卷：254
- 期：Complete
- 页码：32-36
- 全文大小：395 K
文摘
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Novel radioligand binding assay for accurate determination of retinoid X receptors binding capabilities.
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Optimal conditions for 9-cis retinoic acid specific binding to its cognate nuclear retinoid X receptors.
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Endocrine disruptors trialkyltin and triphenyltin have been confirmed as RXR ligands by radioligand binding assay.
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